Friday, March 14, 2014

What is acetaminophen? How does it interact with other drugs?


Milk Thistle, Coenzyme Q10 (CoQ10), Methionine


Effect: Possible Helpful Interactions




The herb milk thistle and the supplements CoQ10 and methionine might help protect the liver against damage caused by excessive use of acetaminophen. However, it is extremely dangerous to take excessive amounts of acetaminophen.




Vitamin C


Effect: Possible Increased Risk of Toxicity


One study from the 1970s suggests that very high doses of vitamin C (3
grams daily) might increase the levels of acetaminophen in the body. This could
potentially put a person at higher risk for acetaminophen toxicity. Problems might
occur if one takes higher-than-recommended doses or takes high doses of
acetaminophen on a regular basis, such as for osteoarthritis. The risk increases if one has liver or
kidney impairment or drinks alcoholic beverages regularly, which further harms the
liver.




Chaparral, Comfrey, and Coltsfoot


Effect: Possible Harmful Interaction


The herbs chaparral (Larrea tridentata or L. mexicana), comfrey (Symphytum officinale), and coltsfoot (Tussilago farfara) contain liver-toxic substances. Combined use with acetaminophen could accentuate the liver toxicity of the medication.




Citrate


Effect: Possible Harmful Interaction


Potassium citrate, sodium citrate, and potassium-magnesium citrate are
sometimes used to prevent kidney stones. These supplements reduce
urinary acidity and can therefore lead to decreased blood levels and decreased
effectiveness of acetaminophen.




Bibliography


Muriel, P., et al. “Silymarin Protects Against Paracetamol-Induced Lipid Peroxidation and Liver Damage.” Journal of Applied Toxicology 12 (1992): 439-442.



Neuvonen, P. J., et al. “Methionine in Paracetamol Tablets: A Tool to Reduce Paracetamol Toxicity.” International Journal of Clinical Pharmacology, Therapy, and Toxicology 23 (1985): 497-500.




2011 PDR for Nonprescription Drugs, Dietary Supplements, and Herbs. Toronto, Ont.: Thomson Health Care, 2010.

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