Sunday, March 30, 2014

What are some themes in the poem "The Raven" by Edgar Allan Poe?

In "The Raven," Edgar Allan Poe employs a Gothic ambiance to explore themes of grief, negativity, and depression. As the poem opens, the narrator is at home alone at night feeling sad and lonely. He is reading to try to forget about his "sorrow for the lost Lenore." His lost loved one so fills his thoughts that at various times in the poem he believes she is near him, perhaps in the form of a spirit, ghost, or angel. That is why the rustling of the curtains and the mysterious knocking "thrilled me—filled me with fantastic terrors never felt before." Later he thinks he hears her footsteps and smells her perfume. His grief is affecting his mind, and thoughts of his departed loved one overtake him so that he imagines her presence. This theme portrays how grief dominates the mind of one who has recently lost a loved one to the extent that his imagination can get carried away.


Sadly, the man's grief leads to negativity and doubt. Although he allows the bird to entertain him for a short while, he soon succumbs to doubts about whether he will see Lenore again in the afterlife and whether he will ever be able to "forget" her in this life and heal from the pain of his intense grief. This leads him to ask the wrong questions of the bird. Knowing the bird is only capable of saying a single word and that "what it utters is its only stock and store," the narrator nevertheless asks a question that is sure to bring an answer of despair. This points out that when one asks the wrong question, one gets the wrong answer. Ironically, a person who is swathed in negativity only asks negative questions that confirm the despair he feels. 


Finally, depression is a major topic of the poem. As the man sinks further into grief and negativity, he finds himself drowning is a disabling sea of depression. The bird's beak in his heart, its eyes demonically gleaming at him, and its shadow enveloping him are symbolic of the depression that immobilizes him and makes him believe that he will feel that way forever. In this way, the poem suggests that grief and negativity can produce long-term depression in a person who has lost a loved one and is experiencing extreme loneliness. 

Saturday, March 29, 2014

Does water and carbon dioxide form while burning a candle ?

Q: 


When burning a candle, do water and carbon dioxide form?


A: 


Assuming the candle wick is made out of organic compounds (usually wicks are braided cotton, which is made up of organic compounds), the answer is yes.


The reason water and carbon dioxide form when burning a candle is because burning a candle wick is a form of combustion of organic molecules. Combustion, which we usually think of as "burning" or "fire", is really just a chemical reaction in which molecules react with oxygen from the air. We experience this as fire, but really, in the case of wood or a candle, it is hydrocarbons (organic molecules) combining with oxygen from the air to form chemical products. Combustion reactions involving organic molecules have the following form:


`X + O_2 + heat-> CO_2 + H_2 O + heat`


In the above, the left side are the reactants and the right side are the products (you can read the arrow as "yields" or "produces"). in the above stands for the fuel. In combustion, the fuel is some organic molecule, that is, a particular type of molecule made up of some combination of carbon, hydrogen, and oxygen. In other words, in an organic combustion reaction, organic molecules--along with oxygen and heat--produce carbon dioxide, water, and more heat. This is the general form of a complete combustion reaction.


Candle wicks are made of organic molecules. When candle wicks are heated to a certain point in the presence of oxygen, they burn, forming carbon dioxide and water, as well as heat.

When in Macbeth do Macbeth and Lady Macbeth show fear of damnation?

Macbeth demonstrates fear of damnation in Act II, Scene 2. Lady Macbeth's guilt is slower to develop; she is not consumed with guilt for the crime of regicide or Banquo's death until Act V, Scene 1.


Knowing that regicide is a serious crime, certainly for the act itself and also because it disrupts the order of creation in the Great Chain of Being—the idea of a perfect hierarchy from God down to the most insignificant creature on earth—Macbeth is overcome with fear and guilt after his murder of King Duncan. Following his heinous act, he tells Lady Macbeth,



Methough I heard a voice cry "Sleep no more!
Macbeth does murder sleep"—....
"Glamis hath murdered sleep, and therefore Cawdor
Shall sleep no more: Macbeth shall sleep no more." (2.2.35-43)



At this point Lady Macbeth berates her husband, telling him to get water and just wash the "filthy business" from his hands. Further, she dismisses his fears by saying,



The sleeping and the dead


Are but as pictures. (2.2.53-54)



However, by Act V, Lady Macbeth has no mettle and is so overcome by guilt that she has lost her mind and is obsessed with images of Duncan's blood on the steps of the castle. Ironically, now it she who can no longer sleep; rather, she sleepwalks, and in her delusions she tries to wash the spots of blood out of the stone steps.



Out, damned spot! Out, I say...
Hell is murky...
Yet who would have thought the old man to have had so much blood in him? (5.1.25-28)



Further, she imagines that she tells Macbeth that Banquo cannot come out of his grave: "What's done is done!"(5.1.46). Clearly, her conscience is tortured by the murders of both Duncan and Banquo. Hearing her, the physician remarks, "I think, but dare not speak" (5.1.57) as he suspects that Lady Macbeth and Macbeth have committed grievous crimes, and now she is disturbed by her part in these murderous acts.

Why did southerners believe that they had lost political power in the national government?

In this question, I assume you are referring to the time period around the Civil War. The South believed it was losing political power in the federal government. The South was concerned about the direction events were heading in our country politically. There were more people living in northern states. This gave the North a majority in the House of Representatives. The South was concerned that more free states would join the Union, which would weaken southern influence in the Senate because they would be outnumbered by senators from the free states.


The South was also divided politically. The Democratic Party was divided between the Northern Democrats and the Southern Democrats. The Democrats lost the election of 1860 to Abraham Lincoln and to the Republican Party. The southerners were convinced this would lead to policies that would harm the South. They knew their chances of keeping an equal balance between the free states and the slaves was dwindling. The South was very worried they wouldn’t be able to pass laws that would positively benefit the South.

Thursday, March 27, 2014

What were the advantages and disadvantages of Jamestown?

One advantage of Jamestown was that its location was far enough up the James River that it was easily defended from attack from Spanish ships. Spanish attacks had ravaged English settlements before, and Jamestown was intended in part to serve as a strategic barrier to Spanish expansion up the east coast. So this was a real advantage. Another advantage, though one not immediately evident, was the suitability of the local climate and soils for cultivating tobacco, which became a staple crop of the colony a little over ten years after the initial settlement. The list of disadvantages was far longer. The location of the settlement lacked a consistent supply of fresh water, being in the tidal region of the James River. It was also low-lying, which meant that the colonists were constantly exposed to disease-bearing mosquitos. Moreover, it was squarely in the middle of a region dominated by the powerful Powhatan Confederacy. While the colonists maintained friendly relations with these Indian peoples, they proved to be valuable allies. When the colonists did not, they were tough and implacable enemies. Finally, the colony's location did not allow the English colonists to duplicate what the Spanish had done in South and Central America. It lacked the precious metals that the English hoped to discover, and they were forced to come up with a new plan for colonization that only really worked out in the long run, and after many deaths.

What are the similarities and differences between Alyssa Brugman's novel Walking Naked and the movie Mean Girls?

Both the film Mean Girls and the novel Walking Naked focus on the sort of fierce competition many teenage girls find themselves engaged in. While they have much in common, they do differ in some aspects of their content.


Both tales feature a "popularity princess" character. In Mean Girls, this is the character of Regina George, who we get to know through the experiences of outsider turned Queen Bee, Cady Heron. In contrast, Walking Naked is told through the eyes of Megan Tuw. Megan is the leader of the most popular clique in her school, and here we must get to know the "freak" through her telling of the story. In a way, Regina George and Megan Tuw represent two ways of approaching the same character archetype-- one from the inside, one from the outside.


These cliques of popular girls are, in both tales, made up of wealthy, stylish, and pretty young women. However privileged the members of the Plastics and the Clique may be in their sect of society, they feel an extreme sense of competition with each other. Wearing the wrong hairstyle or color is grounds for being banished from the social group. I think this is a great example of how women (and girls) can often be the toughest critics of each other for failing to ascribe to a male-gaze construction of beauty and femininity. Also interesting to me are the ways in which Mean Girls and Walking Naked differ in their conceptualization of the social groups teenagers form. In Walking Naked, there is a pretty strong divide between people who are popular and those who are not. You are one or the other. Yet in Mean Girls, we are introduced to a wide variety of social groups with differing characteristics beyond a relative degree of popularity based on wealth and physical appearance.


Though I've already mentioned a little bit of the power dynamics at work in these media, I'd like to focus more specifically on the relationship between the character archetypes of the popularity princess and the freak. In Walking Naked, this is the relationship between Megan and Perdita. In all the ways that Megan is socially privileged, Perdita is strange and cast out. The two develop a secret and unlikely friendship, one which causes Megan to feel a lot of shame. Megan values her own appearance-- including the appearance of her social relationships-- over the connection she felt with Perdita, and she sadly loses this friend for good. In this case, the story ends with Megan maintaining her social status at the expense of her conscience.


Now let's compare with the relationship between Queen Bee Regina George and "wannabe" Cady Heron. (I purposefully reference here the text the film is based off of- Queen Bees and Wannabes by Rosalind Wiseman.) In Mean Girls, Cady moves to America after having been homeschooled by her parents while they did research in Africa. For the first time, she is thrust into the complex web of social life that is the American high school. In a power play intended to mark Cady as Other, Regina compliments her and invites her to share an exclusive seat at the lunch table of the Plastics. Regina intends to integrate Cady into their group as a sort of pet to make herself seem more interesting, but the other members of the group begin to like Cady more than Regina. At the end of the film, Cady has torn down all of Regina's social privileges at the urging of one-time Plastic, Janis Ian. These social and emotional blows to Regina's identity, along with being hit by a bus, really serve as a wake up call. In the end, Cady, Regina, and the other girls achieve a far more even playing field than they first encountered.


These two representations of the un/popular power dynamic present two ways we can consider social inequality and competition. With Walking Naked, we see the unfortunate possibility that people who are at a disadvantage in life often succumb to their struggles. On the other hand, we can consider Mean Girls as a sort of social revolution! Cady could have, by all means, maintained the socially disadvantaged, outsider status she experiences when she first arrives at her new high school. The clever plays of Janis Ian, combined with Cady's increasing status, serve to overthrow Regina George and the "old regime" of popularity. 


Beyond such in-depth textual analysis, both Mean Girls and Walking Naked approach the subjects of social competition and girl-on-girl bullying in a way that really reaches their intended audience-- teen girls. Depending on a reader's own social status, they may interpret either text as a story of heroism or a warning.

Monday, March 24, 2014

How can one deal with lack of discipline in the classroom?

There are limits to what teachers can do to maintain discipline in a classroom. Many of the factors that affect classroom behavior, including home environment, class size, and even student personalities, are beyond the control of the teacher. 


The first thing you need to do is set clear boundaries and guidelines. Often children (especially teens), as part of their own attempts to build independent identities, will push the limits of any rules or conventions; making rule systems transparent, fair, and consistently enforced actually gives the students a sort of stability that they find reassuring. This means that all classroom rules should be simple, clear, explained to students in terms they can understand, and enforced. 


Next, students with disabilities or behavioral problems should be referred to the appropriate staff to get the treatment they need. Accommodation plans for special needs students will reduce the likelihood that they will become discipline problems. 


Rules and punishments for infractions should conform to all relevant school and departmental guidelines. The better the support you have from upper administration, the more effectively you will be able to maintain discipline through methods such as reporting, detention, suspension, and parental involvement.


As a teacher, you should remain calm and professional at all times, creating an orderly and focused classroom that engages student interest. When students do push boundaries, avoid arguing with them or losing your temper, but remain calm, cheerful and firm. Enlist your students to work with you to create a positive classroom environment. Be aware of what is going on in every part of your classroom so that you can deal with potential problems before they escalate. Praise and positively reward good behavior.

In Reading Lolita in Tehran by Azar Nafisi, how are the women able to find empowerment?

For the author of Reading Lolita in Tehran, teaching the class in her home to women is a form of empowerment. As she writes, "This class was the color of my dreams. It entailed an active withdrawal from a reality that had turned hostile. I wanted very badly to hold on to my rare mood of jubilance and optimism" (page 8). After she is harassed at the university and resigns, Azar Nafisi finds empowerment by teaching literature to women who truly want to learn. She writes about the class as "the color of my dreams," as opposed to the drab reality around her in oppressive Tehran. 


The women who attend the class find it empowering because they can voice their true feelings and literally and figuratively let down their hair. For example, when Sanaz enters the class, Nafisi describes Sanaz's transformation after she removes her scarf and robe: "She was wearing an orange T-shirt tucked into tight jeans and brown boots, yet the most radical transformation was the mass of shimmering dark brown hair that now framed her face" (page 18). The women's hair is a form of freedom and expression that they cannot show in the streets of Tehran. Nafisi records the women's feelings and innermost cares as they attend the class. For example, she records, "Some of my girls are more radical than I am in their resentment of men. All of them want to be independent" (page 26). The more they read, the more they understand the terms of their own imprisonment in Tehran. For example, they read Nabokov's Lolita and find the references to the way that Humbert jails Lolita similar to the way men imprison them psychologically and physically in their own society (page 25). They also discuss the ways in which Humbert robs Lolita of a true childhood, just as they have been robbed. As they continue to read literature, they become more and more independent minded.


After the class, many of the women find their way out of Iran--to England (in Nassrin's case), the United States, and Canada. Others, such as Yassi, pursue graduate studies in literature and lead their own classes, as the class has empowered them to think of themselves as readers and thinkers. The women who are left in Iran continue to read western literature. The paths they have taken reflect their sense of growing empowerment. 

What are chitosan's therapeutic uses?


Overview

Chitosan is a form of fiber chemically processed from
crustacean shells. Like other forms of fiber, such as oat bran, chitosan is not
well digested by the human body. As it passes through the digestive tract, it
seems to have an ability to bond with ingested fat and carry it out in the stool.
For this reason, it has been tried as an agent for lowering cholesterol and
reducing weight. However, the results in studies have been more negative than
positive. In addition, chitosan has been tried as a treatment for kidney failure
and as an aid in wound healing.





Requirements and Sources

Chitosan can be extracted from the shells of shrimp, crab, or lobster. It is also found in yeast and some fungi. Another inexpensive source of chitin is squid pens, a by-product of squid processing; these are small, plastic-like, inedible pieces of squid that are removed before the squid is consumed.




Therapeutic Dosages

The standard dosage of chitosan is 3 to 6 grams (g) per day, to be taken with food. Chitosan can deplete the body of certain minerals. For this reason, when using chitosan, it may be helpful to take supplemental calcium, vitamin D, selenium, magnesium, and other minerals. Also, according to a preliminary study in rats, taking vitamin C along with chitosan might provide additional benefit in lowering cholesterol.




Therapeutic Uses

On the basis of chitosan’s supposed ability to bind fat in the intestines, it has been tried as a treatment for high cholesterol. However, the evidence regarding whether it really works is generally more negative than positive. At best, chitosan appears to offer no more than minimal benefit for high cholesterol.


Chitosan has also been proposed as a weight-loss treatment on the same principle. However, despite some mildly positive results, the current balance of evidence suggests chitosan does not in fact significantly aid weight loss.


Weak evidence hints that chitosan may be helpful in kidney failure. When used for this purpose, it is thought to work by binding with toxins in the digestive tract and causing them to be excreted.


Studies in dogs have found that topically applied chitosan can help heal wounds. This effect might be caused by stimulation of new tissue growth; in addition, topical chitosan appears to kill bacteria such as those in the Streptococcus species, which may also contribute to wound healing. Chitosan may also have activity against Candida albicans, a form of yeast that causes vaginal infections.


Highly preliminary evidence suggests that oral chitosan may inhibit the expected rise in blood pressure after a high-salt meal. Other weak evidence hints that chitosan chewing gum might help prevent cavities. It has been suggested that chitosan can stimulate the immune system and prevent cancer, but there is no reliable evidence as yet that it offers these benefits.


Animal studies suggest that some forms of chitosan may help to prevent bone loss; however, because chitosan also interferes with mineral absorption, the net effect in humans might actually be to increase bone loss.




Scientific Evidence


High cholesterol. An eight-week double-blind, placebo-controlled
trial of fifty-one women found that use of chitosan at a dose of 1,200 milligrams
(mg) twice daily slightly reduced low density lipoproteins (LDL, or bad
cholesterol) compared with a placebo but did not affect total or high density
lipoprotein (HDL, or good cholesterol) levels. Another
eight-week trial, this one enrolling eighty-four people, also found modest
benefits.


However, a four-month double-blind, placebo-controlled trial of 88 individuals found no improvement in cholesterol with 1,000 mg three times daily of a different chitosan product. A seven-month study of 84 men given a placebo or 1,200 mg of chitosan daily also failed to find any benefit. Furthermore, in a ten-month double-blind, placebo-controlled study of 130 men and women, use of a special microcrystalline form of chitosan at a dose of 1,200 mg twice daily again failed to improve cholesterol profile. These contradictory results suggest that if chitosan actually improves cholesterol profile, it does so to only a minimal extent.



Weight loss. Chitosan has been widely advocated as a weight-loss supplement on the basis of its supposed ability to bind fat in the digestive tract. However, despite some positive results, the largest and best-designed trial failed to find benefit. In this six-month double-blind, placebo-controlled study of 250 overweight people, use of chitosan at a dose of 3 g daily failed to enhance weight loss to any meaningful extent, compared with a placebo.



Kidney failure. People with kidney failure experience numerous
health problems, including anemia, fatigue, and loss of appetite.
In one open study, researchers tested chitosan supplements in eighty people with
kidney failure receiving ongoing hemodialysis treatment. Half the participants
were given 45 mg tablets for a total of about 1,500 mg of chitosan daily for
twelve weeks; the other half were not given a supplement. Those in the treatment
group showed a significant decrease in urea and creatinine levels. Further, they
had a rise in hemoglobin levels and reported improved overall strength,
appetite, and sleep.




Safety Issues

There is significant evidence that long-term, high-dose chitosan
supplementation can result in malabsorption of some crucial vitamins and minerals,
including calcium, magnesium, selenium, and vitamins A, D, E, and K. In turn, this
appears to lead to a risk of osteoporosis in adults and delayed
growth in children. For this reason, adults taking chitosan should also take
supplemental vitamins and minerals, making especially sure to get enough vitamin
D, calcium, and magnesium. Another possible risk of long-term ingestion of high
doses of chitosan is that it could change the intestinal flora and allow the
growth of unhealthful bacteria.


Finally, there has been a case report of arsenic
poisoning caused by long-term use of chitosan supplements.
Shellfish, it appears, can concentrate arsenic in their shells as part of their
normal development; this in turn may lead to arsenic-laced chitosan supplements.
Pregnant or nursing women and young children should probably avoid chitosan
altogether.




Bibliography


Bokura, H., and S. Kobayashi. “Chitosan Decreases Total Cholesterol in Women.” European Journal of Clinical Nutrition 57 (2003): 721-725.



Guha, S., et al. “Effect of Chitosan on Lipid Levels When Administered Concurrently with Atorvastatin.” Journal of the Indian Medical Association 103 (2005): 418, 420.



Ho, S. C., et al. “In the Absence of Dietary Surveillance, Chitosan Does Not Reduce Plasma Lipids or Obesity in Hypercholesterolaemic Obese Asian Subjects.” Singapore Medical Journal 42 (2001): 6-10.



Lehtimaki, T., et al. “Microcrystalline Chitosan Is Ineffective to Decrease Plasma Lipids in Both Apolipoprotein E Epsilon4 Carriers and Non-carriers: A Long-term Placebo-Controlled Trial in Hypercholesterolaemic Volunteers.” Basic and Clinical Pharmacology and Toxicology 97 (2005): 98-103.



Metso, S., et al. “The Effect of Long-term Microcrystalline Chitosan Therapy on Plasma Lipids and Glucose Concentrations in Subjects with Increased Plasma Total Cholesterol.” European Journal of Clinical Pharmacology 59, no. 10 (2003): 721-726.



Mhurchu, C. N., et al. “The Effect of the Dietary Supplement, Chitosan, on Body Weight: A Randomised Controlled Trial in 250 Overweight and Obese Adults.” International Journal of Obesity and Related Metabolic Disorders 28 (2004): 1149-1156.



Schiller, R. N., et al. “A Randomized, Double-Blind, Placebo-Controlled Study Examining the Effects of a Rapidly Soluble Chitosan Dietary Supplement on Weight Loss and Body Composition in Overweight and Mildly Obese Individuals.” Journal of the American Nutraceutical Association 4 (2001): 42-49.

What is the connection of the word "gift" to the book Hatchet?

The hatchet that Brian uses in the story was a gift from his mother.


When Brian’s mother gave him the hatchet, neither of them knew how important it would be. She just assumed that he might have some adventures in the wilderness. She never thought the plane would crash.


Brian was very emotional when he said good-bye to his mother. His parents were getting a divorce, and that was all he could think about. His reaction to the hatchet is ambivalence. He does not want to tell her that he doesn’t really want it, and that he is upset.



And he would normally have said no, would normally have said no that it looked too hokey to have a hatchet on your belt. Those were the normal things he would say. But her voice was thin, had a sound like something thin that would break if you touched it, and he felt bad for not speaking to her. (Ch. 1) 



Brian lets her put the hatchet on his belt. He does not give it much thought. When he gets into the plane, it is still there. When he notices it, he is a little embarrassed. The pilot says nothing. The plane is small, and Brian and the pilot are the only ones onboard.


His mother gave him money for food, in case he was “stranded” at the airport. Brian gets stranded, but not at the airport. The pilot has a heart attack, and the plane crashes into a lake in the middle of the wild.



And on his belt, somehow still there, the hatchet his mother had given him. He had forgotten it and now reached around and took it out and put it in the grass. There was a touch of rust already forming on the cutting edge of the blade and he rubbed it off with his thumb. (Ch. 5)



The hatchet is the only survival tool Brian has. He has a little trouble finding food, but is able to use the hatchet to create a fishing spear, and later to cut into the plane and get the survival kit. The hatchet is the reason Brian lives, so it was quite an appropriate gift.

Saturday, March 22, 2014

If an object covers distance in direct proportion to the square of the time elapsed, then the acceleration is constant. Why?

In the given scenario,


d `alpha` t^2


where, d is the distance covered and t is the time taken.


Let us try to prove that if an object has a constant acceleration then the distance covered is directly proportional to the square of time taken.  


Now, acceleration = rate of change of velocity


or, a = (final velocity - initial velocity)/time = (Vf - Vi)/t


or, Vf = Vi + at


and distance traveled = average velocity x time = (Vinitial + Vfinal)/2 x t 


= (Vi + Vf)/2 x t


or, d = (Vi + Vi + at)/2 x t = Vi x t + 1/2 at^2


If the motion started from rest, that is, the object accelerated from zero velocity, Vi = 0 and,


d = 1/2 at^2


Thus, we can see that if the object starts from rest and accelerates at a constant acceleration, the distance covered is directly proportional to the square of the time elapsed. 


Free fall of an object is a good example of such a motion. 


Hope this helps. 

Friday, March 21, 2014

What are oncogenes?


Discovering Oncogenes

Identifying oncogenes was closely linked to study of the role of certain RNA tumor viruses, retroviruses (Retroviridae), in the etiology of many animal cancers. In 1911, Francis Peyton Rous identified a chicken virus (now called Rous sarcoma virus) that, when injected into healthy chickens, was capable of inducing malignancies called sarcomas. Unexpectedly, these viruses had RNA instead of DNA as their genetic signature. Doctrine had always held that DNA preceded and in effect fathered RNA. The peculiar idea that a virus could spread cancer was largely ignored for some time thereafter; not until more than fifty years later, in 1966, did Rous receive a Nobel Prize for his work.









Because the Rous virus had RNA rather than DNA in its genome (all genes in an organism), researcher Howard Temin predicted that animal retroviruses might propagate “backward” by transcribing their RNA genome into DNA. By the late 1950s Temin’s prediction was validated. RNA tumor viruses indeed work backward, carrying viral oncogenes that, having invaded normal cells, transform them into cancer cells and then withdraw to find other cells to infect, at times adopting a section of the host cell’s genome as they go. In the 1970s both Temin and David Baltimore independently published evidence of a viral enzyme, reverse transcriptase, contained in retroviruses that performs the actual conversion of RNA into DNA. Multiple RNA tumor viruses capable of causing tumors in animals or experimental systems were later discovered, fueling a search for specific viral genes responsible for the cancer-causing properties of these viruses. As well, the search was on for the elusive and initially questioned human retroviruses. Recombinant DNA technology and molecular genetics ultimately revealed that viral oncogenes are actually normal cellular genes incorporated into the genetic material of the RNA tumor virus during infection.


Oncogenes are labeled with such three-letter abbreviations as mas or myc. Viral oncogenes carry the prefix “v-” for virus, while cellular oncogenes are preceded by “c-” for cell or chromosome. More information about the oncogene is conveyed by other alphabetic appendages. The first oncogene discovered was the src gene of the Rous sarcoma virus. Subsequently, a host of different oncogenes was discovered in avian and mammalian RNA tumor viruses. These oncogenes have a cellular counterpart that is the presumed origin of the viral gene; incorporation of the host-cell gene into the virus (called transduction) abridges viral genes, generating a defective virus. The first human retrovirus found, HTLV-1, is almost identical to ones detected in primates and supports a long-ago leap from primate to human.




Properties of Oncogenes

The first dramatic evidence linking oncogenes with cancer was provided by studies of the sis oncogene of simian sarcoma virus, which proved to be an altered form of mammalian platelet-derived growth factor (PDGF). Growth factors are proteins that bind to receptors on target cells and begin an intracellular signaling cascade, inducing growth. This seminal discovery underlies the proto-oncogene model, holding that oncogenes are derived from normal proto-oncogenes. Should proto-oncogene expression be altered somehow, normal cell division may be disrupted and cellular proliferation, a hallmark of malignancy, results.


Subsequent data have corroborated this model. Viral and cellular oncogenes have been identified with functions affecting every step in cellular control. In addition to altered growth factors, researchers have also identified altered growth factor receptors such as the epidermal growth factor receptor (erb-b), elements of the intracellular signal cascade(src and ras), nuclear transcriptional activators (myc), cell-cycle regulators called cyclin-dependent kinases (cdks), and cell-death inhibitors (bc12) in human tumors of diverse tissue origin. Each of these oncogenic gene products displays an altered form of normal cellular genes that participates in cell division.


Infective retroviruses are not the only way to activate proto-oncogenes. Mutations to genes and structural changes among chromosomes can activate proto-oncogenes during normal cell division. A point mutation, or alteration of a single nucleotide base pair, from environmental incidents such as chemical carcinogens, ultraviolet radiation, or X rays, can produce an aberrant protein not subject to normal inhibitions. Certain c-ras proto-oncogenes that normally control growth are converted during cellular division into oncogenes with the growth switch always on. In some cases, single point mutations that exchanged amino acids but encoded the same proteins as those produced normally were considered benign “silent” mutations; it is now known that so-called silent mutations nevertheless can still damage health. The elongated body parts of people with Marfan syndrome result from two silent mutations, and at least fifty other diseases are linked entirely or in part to altered protein production from the aberrant RNA editing of silent mutations. Translocation occurs when a broken-off segment of a chromosome attaches to another chromosome; should the broken segment contain a proto-oncogene, its dysregulation may spawn a profusion of proteins that overwhelms normal cellular processes. The first genetic rearrangement linked to a specific human malignancy involved the “Philadelphia” chromosome in patients with chronic myeloid leukemia (CML)
, where chromosome 22 is shortened from an exchange of genetic material (called reciprocal translocation) between it and chromosome 9. In CML the oncogene abl, originally identified in a mammalian RNA tumor virus, is translocated to chromosome 22. Additional human malignancies involving translocated oncogenes previously identified in RNA tumor viruses have been identified, notably the oncogene myc in patients with Burkitt’s lymphoma
, found primarily in parts of Africa. Amplification, or promiscuous duplication, of copies of a proto-oncogene can also overproduce proteins and forfeit control of cell growth. Gene amplifications may be associated with multiple copies of genetic segments along a chromosome, called homogeneously staining regions (HSRs), or may appear in the form of minichromosomes containing the amplified genes, termed double-minutes (DMs). Late-stage neuroblastomas often contain numerous double-minute chromosomes with amplified copies of the N-myc gene.


It is interesting to note that most tumors thus far analyzed display multiple oncogenes and tumor-suppressor genes
, which, when functioning correctly, suppress tumors. Once a tumor-suppressor gene is impaired, however, that preventive factor is gone. This is not as probable in a tumor-suppressor gene, as according to the two-hit hypothesis, both alleles(genes occupying the same locus on a chromosome) must be defective before it malfunctions. Oncogenes, on the other hand, can mutate with damage to a single allele. To borrow an analogy, if oncogenes are the accelerator in a cancer cell, tumor-suppressor genes are the brakes. In malignancies, the accelerator is floored while the brakes are malfunctioning. Studies of developing human colorectal carcinomas show steady increases in number and types of oncogenes. From these studies, a model of oncogenesis emerges as a multistage disorder characterized by successive mutations in specific oncogenes and tumor-suppressor genes, with consequent explosive growth.




Impact and Applications

Biomarkers, the overexpressed molecular abnormalities peculiar to cancer, are the fingerprints of disease. Molecular imaging through positron emission tomography (PET) and single photon emission computed tomography (SPECT) identifies biomarkers not otherwise detectable. Such techniques can detect abnormalities at low frequencies and so assist in identifying early-stage disease, as well as detect evidence post-treatment of residual disease. In diagnosis, karyotype analysis (staining during certain growth phases) has detected the chromosomal aberrations of lymphoma and certain leukemias. Now that many genes have been cloned, more effective diagnostics are available. Fluorescence in situ hybridization (FISH) locates chromosome abnormalities with molecular probes, which can identify deletions or mark the boundaries of a dislocation. Point mutations and translocations can also be found with such techniques as Southern blotting, which transfers and fixes
DNA sequences, and polymerase chain reaction (PCR), which amplifies DNA in vitro. Exploring our molecular terrain also enables accurate pretreatment testing to predict response.


Researchers are devising specific molecular interventions that target only diseased cells and dramatically decrease side effects compared to conventional chemotherapy. Researchers are designing inhibitors of specific oncogenes and of malignant oncogenic effects such as cellular proliferation and angiogenesis (blood vessel formation), both crucial to tumor establishment. Known structural abnormalities in oncogene products inform development of monoclonal antibodies directed at those proteins. Toxins may be linked to antibodies to generate immunotoxins that seek malignant cells. In CML, a drug now inhibits the enzyme tyrosine kinase that is overproduced from a proto-oncogene translocation. Although tyrosine kinase is active in humans in numerous ways, the drug interferes only with the form specific to the CML mutation. Helping the immune system recognize and combat tumor growth through immunology may one day enable cancer vaccination. Another promising approach arises from the observation that, despite the numerous genetic abnormalities of cancer cells, their continued existence can require a single oncogene; this is called “oncogene addiction.” Debilitating pivotal oncogenes provides impetus for increasingly targeted molecular therapy.




Key terms



proto-oncogenes

:

cellular genes that carry out specific steps in the process of cellular proliferation; as a consequence of mutation or deregulation, they may be converted into cancer-causing genes





retrovirus


:

a virus that converts its RNA genome into a DNA copy that integrates into the host chromosome





Bibliography


Angier, Natalie. Natural Obsessions: Striving to Unlock the Deepest Secrets of the Cancer Cell. Boston: Mariner/Houghton, 1999. Print.



Chamary, J. V., and Laurence D. Hurst. “The Price of Silent Mutations.” Scientific American 300.6 (2009): 46–53. Print.



Cooper, Geoffrey M. Oncogenes. 2d ed. Boston: Jones, 1995. Print.



Ehrlich, Melanie, ed. DNA Alterations in Cancer: Genetic and Epigenetic Changes. Natick: Eaton, 2000. Print.



Gallo, Robert C. “History of the Discoveries of the First Human Retroviruses: HTLV-1 and HTLV-2.” Oncogene 24 (2005): 5926–930. Print.



Hartwell, Leland, et al. “Cell Cycle Control and Cancer.” Science 266 (1994). Print.



Kavsan, V. M. "Structure and Function of Oncogene-Transfected Immortal Cells." Biopolymers & Cell 30.1 (2014): 25–28. Print.



La Thangue, Nicholas B., and Lasantha R. Bandara, eds. Targets for Cancer Chemotherapy: Transcription Factors and Other Nuclear Proteins. Totowa: Humana, 2002. Print.



Mulvihill, John J. Catalog of Human Cancer Genes: McKusick’s Mendelian Inheritance in Man for Clinical and Research Oncologists. Baltimore: Johns Hopkins UP, 1999. Print.



Oikonomou, Eftychia, and Alexander Pintzas. "The Trail of Oncogenes to Apoptosis." Biofactors 39.4 (2013): 343–54. Print.



Varmus, Harold. “The Molecular Genetics of Cellular Oncogenes.” Annual Review of Genetics 18 (1994). Print.



Weinstein, Bernard, and Andrew Joe. “Oncogene Addiction.” Cancer Research 68 (2008): 3077. Print.



Willis, Rudolph E. "Human Gene Control by Vital Oncogenes: Revisiting a Theoretical Model and Its Implications for Targeted Cancer Therapy." Intl. Journ. of Molecular Sciences 13.1 (2012): 316–35. Print.

Wednesday, March 19, 2014

The gravitational potential energy of an 88 kg person in a building that is 385 m tall is 332,024 J. The person then jogs up the stairs, an...

The potential energy of a body is given as the product of its mass (m), acceleration due to gravity (g) and its height (h) with respect to a datum. In this case, the mass of the person, m = 88 kg, and he is at a height of 385 m (= h).


His gravitational potential energy = m x g x h


= 88 kg x 9.8 m/s^2 x 385 m = 332,024 J.


The person jogs up on a set of stairs, a further distance of 100 m. The inclination of stairs is not given, so we cannot determine the additional height gained by the person, without making some assumption. 


Assuming the inclination of stairs to be 30 degrees with the horizontal. Thus, further height gained by the person is 100 sin 30 = 50 m.


Thus, additional potential energy gained = m x g x h'


= 88 kg x 9.8 m/s^2 x 50 m = 43,120 J.


Thus, the potential energy of the person increases as he goes further up (by jogging).


Hope this helps.  

Tuesday, March 18, 2014

Who is Virginia Satir?


Life

Virginia (Pagenkopf) Satir was the oldest of five children born to Alfred and Minnie Pagenkopf. She developed a keen interest in reading at a very young age. By the age of five, she had decided that she would eventually pursue a career that would involve helping families face and solve problems.











During her teenage years, Satir’s family moved to Milwaukee, Wisconsin, so that she could attend high school. In 1936, she earned a BA in education from Milwaukee State Teachers College (now a part of the University of Wisconsin). In 1948, Satir received an MA in social work from the University of Chicago. After her first marriage ended in divorce, she married Norman Satir in 1951. They divorced in 1957.


During much of the 1950s, Satir worked with families at the Dallas Child Guidance Center and at the Illinois State Psychiatric Institute. In 1959, Satir, Don Jackson, Jules Ruskin, and Gregory Bateson started the Mental Research Institute (MRI) in Palo Alto, California, and created the first formal program in family therapy in the United States. Recognized for her insights into human communication and her understanding of interpersonal relationships and development of self-esteem, Satir became known as the Columbus of family therapy and the mother of family system therapy. She strongly believed that if families could be healed and united, then the problems of the world would be solved, and world peace would eventually be established.


In her efforts to teach people how to cope with their problems, Satir presented hundreds of workshops and training seminars throughout the world. Her change-process model focused on personal growth, health, and the worth of each individual. She authored or coauthored twelve books, including Conjoint Family Therapy (1964), Peoplemaking (1972), and The New Peoplemaking (1988), all three of which achieved international success.


In 1976, Satir was awarded the Gold Medal for “outstanding and consistent service to mankind” by the University of Chicago. The following year, she organized the Avanta Network to implement the Satir model to help people develop coping skills that would change their lives and help them handle problems in their relationships. In 1982, the West German government recognized Satir as one of the twelve most influential leaders in the world at that time. When Satir died in 1988, she had become internationally acclaimed as a therapist, educator, and author.




Bibliography


"About Virginia Satir." Virginia Satir Global Network. Satir Global, n.d. Web. 12 June 2014.



Andreas, Steven. Virginia Satir: The Patterns of Her Magic. Palo Alto.: Science and Behavior, 1991. Print.



Friedlander, Myrna L. Therapeutic Alliances in Couple and Family Therapy: An Empirically Informed Guide to Practice. Washington, DC: Amer. Psychological Assn., 2006. Print.



Jones-Smith, Elsie. Theories of Counseling and Psychotherapy: An Integrative Approach. London: Sage, 2012. Print.



Rambo, Anne Hearon. Family Therapy Review: Contrasting Contemporary Models. New York: Routledge, 2013. Print.



Wilcoxon, S. Allen. Ethical, Legal, and Professional Issues in the Practice of Marriage and Family Therapy. Upper Saddle River: Pearson, 2007. Print.

What are groups, and how do they affect social behavior?


Introduction

In any newspaper, one is likely to find several captivating stories that highlight the powerful negative influence that groups can exert on individuals. For example, one may recall the tragic violence exhibited by rival Egyptian sports fans during a post–soccer match riot in Port Said in early 2012, resulting in seventy-three deaths.







There are equally dramatic instances of the powerful positive influences of groups. In September 2011, when a car crashed into young motorcyclist Brandon Wright of Utah University, setting his bike ablaze and pinning him beneath, a dozen or so bystanders lifted the car, despite the risk that it might explode. A few years later, in March 2014, bystanders and lifeguards rushed to the aid of a woman and her three children when their minivan plunged into the ocean off Daytona Beach, Florida, and began to sink. This type of bystander intervention, or lack thereof, has been the subject of much psychological study, particularly following the brutal stabbing death of Kitty Genovese within hearing of her neighbors in 1964.


These real-life events are noteworthy because they illustrate the universality of groups and the various ways that groups influence individual behavior. Although everyone can attest the prevalence of groups and the power that they can wield over individuals, several characteristics of groups are not as well defined. Several questions remain as to what groups are, how groups form, what groups look like, and the disadvantages and advantages of group membership. In spite of these questions, psychologists have come to understand many aspects of groups and the ways in which they influence individual behavior.




Definition and Formation of Groups

The members of Congress who compose the House of Representatives of the United States are a group. The urban committee deciding how to allocate budgetary resources for unwed mothers in a particular city is a group. The members of a carpool sharing a ride to the train station every day are a group. The family seated around the dinner table at home in the evening is a group. The acting troupe performing a Shakespearean play is a group. There are other examples of groups, however, that may be a little less obvious. All the unwed mothers in an urban area might be considered a group. A line of people waiting to buy tickets to a Broadway show might be thought of as a group. People eating dinner at the same time in a diner might even be considered a group. The people in the audience who are watching an acting troupe perform could behave as a group.


There are several ways in which people come to join the groups to which they belong. People are born into some groups. Several types of groupings are influenced in large part by birth: family, socioeconomic status, class, race, and religion. Other groups are formed largely by happenstance: for example, a line of the same people waiting for the 8:05 ferry every day. Some groups, however, are determined more clearly by intentional, goal-oriented factors. For example, a group of people at work who share a common concern for well-being, health, and fitness may decide to form an exercise and nutrition group. Students interested in putting on a concert might decide to form a committee to organize bake sales, car washes, and fund drives to raise the money needed to achieve this goal. Finally, group memberships are sometimes created or changed as an effort toward self-definition or self-validation. For example, one can try to change one’s religion, political orientation, professional associations, friendships, or family in an effort to enhance how one feels about oneself—or how others feel about one. An individual searching for a positive self-definition may join a country club, for example, to benefit from the social status acquired from such group membership.




Stages of Group Development

Although there are countless underlying reasons for someone’s membership in a given group, the work of Bruce Tuckman suggests that groups progress through a relatively consistent series of stages or phases—forming, storming, norming, performing, and adjourning—in their development. "Forming" refers to a phase of coming together and orientation. Group members become acquainted with one another and define the requirements of group membership as well as the tasks to be performed. "Storming" refers to a phase of polarization and conflict. During this phase, group members deal with disagreements, compete for attractive positions within the group, and may become dissatisfied with other group members or with the group as a whole. "Norming" refers to a phase when conflicts are solved and group members arrive at agreements regarding definitions of tasks and the requirements of group membership. "Performing" refers to the phase when group members concentrate on achieving their major task and strive toward shared goals. Finally, for some groups, "adjourning" refers to the disbanding or dissolution of the group after task completion.


For example, consider a special task force created to search for a missing child. During the forming stage, the members of this group will volunteer for, or be appointed to, the group. Although the general goals and definition of the group may have been established with the decision to implement such a task force, a storming phase would occur that would lead the group members into the sometimes difficult task of defining specific procedures of operation, responsibilities of particular task force members, a functional hierarchy, and so on. The norming phase would represent the resolution of the polarizations that emerged during the storming phase, as the committee proceeded to establish an agenda, a decision structure, and a means of implementing decisions. During the performing phase, the task force would actually perform the tasks agreed on during the norming phase. Having finished its task, the group would then be adjourned.




Group Topography

The topography of a group refers to its physical features. This includes such elements as the size of the group, the composition of the group, and the relationships among the various members of the group. These topographical features of groups have been the focus of countless studies.


One obvious physical feature that could vary from one group to another is size. Some scholars have categorized group types in terms of size. For example, some researchers have found it useful to distinguish between small primary groups (from two to twenty group members), small nonprimary groups (from three to a hundred members), large groups (one thousand to ten thousand members), and largest groups (ten thousand-plus members). While such classifications may be interesting, the realities of everyday groups are typically more modest than such grand schemes would suggest. In a large number of settings, naturally occurring, free-forming groups typically range in size from two to seven persons, with a mean of about three. There are certainly exceptions to this rule of thumb; for example, most audiences watching theater troupes are considerably larger than three people. Nevertheless, most of the groups in which people interact on a day-to-day basis are relatively small. The size of a group tends to set the stage for many other topographical features of group life.




Variations in Group Composition

The number of relationships possible in a group, according to James H. S. Bosard, is a direct consequence of the size of the group: the larger the group, the larger the number of possible relationships the individual might find within the group. It is possible to express the precise mathematical function relating the number of possible relationships between individuals in a group and group size (n): this function is represented by the formula (n2 − n)/2. For example, if the group is made of Tom and Dick, there is only one possible relationship between members of the group (Tom-Dick). If the group is made up of the three people (Tom, Dick, and Harry), there are three possible relationships (Tom-Dick, Tom-Harry, and Dick-Harry). If the group is made up of seven people, there are twenty-one possible relationships between individuals; if there are ten people in the group, there are forty-five possible relationships between individuals.


Thus, groups have the potential to become increasingly complex as the number of people in the group increases. There are many possible consequences of this increasing complexity. For one thing, it becomes increasingly harder to pay an equal amount of attention to everyone in the group as it increases in size. Brian Mullen and colleagues state that the person in the group who talks the most is paid the most attention and in turn is most likely to emerge as the leader of the group; this effect (sometimes referred to as the “blabbermouth” theory of leadership) increases as the size of the group increases. It also becomes increasingly difficult to get to know everyone in the group and to spend equal amounts of time with everyone in the group as the group increases in size.




Simplifying Group Complexity

People in groups may tend toward a convenient simplification of this inevitable complexity. Scholars have long recognized the tendency for group members to divide other group members into groups of “us” and “them,” ingroups and outgroups, rather than to perceive each person as a distinct entity. Groups can often be divided into perceptually distinct, smaller groups. For example, a committee might be composed predominantly of elderly members, with only one or a few young members. The general tendency is for people to focus their attention on the smaller group. The reason for this is that the smaller group seems to “stand out” as a perceptual figure against the background of the larger group. Thus, the youthful member of an otherwise elderly committee is likely to attract a disproportionate amount of attention from the committee members.


Not only will the members of the larger group pay more attention to the smaller group, but the members of the smaller group will do so as well. Thus, the members of the smaller group will become more self-attentive, more aware of themselves and their behavior. On the other hand, the members of the larger group become less self-attentive, or, as Ed Diener contends, more deindividuated—less aware of themselves and their behavior. For example, the single female in a group of mechanical engineers that is otherwise male will quickly stand out. The male mechanical engineers may tend to think of that one distinct individual in terms of her status as a female. Moreover, the lone female may become more sensitive than usual about her behavioral transgressions of the norms guiding sexual roles in an all-male working environment.




Implications for Social Behavior

Thus, group composition has been demonstrated to predict the extent to which people pay attention to, and are aware of, themselves and specific facets of themselves and to predict a variety of social behaviors, including participation in religious groups, bystander intervention in emergencies, worker productivity, stuttering in front of an audience, and conformity.


For example, an analysis of the participation of congregation members in their religious groups documented the powerful effect of group composition on behavior of group members. As the size of the congregation increased relative to the number of ministers, the congregation members were less likely to participate in the group (in terms of activities such as attending worship services, becoming lay ministers, or “inquiring for Christ”). In this instance, becoming “lost in the crowd” impaired the normal self-regulation behaviors necessary for participation. Alternatively, analysis of the behavior of stutterers in front of an audience also documented the powerful effects of group composition on the behavior of group members. As the size of the audience increased relative to the number of stutterers speaking, the verbal disfluencies (stuttering and stammering) of the speakers increased. In this instance, becoming the center of attention exaggerated the normal self-regulation behaviors necessary for speech, to the point of interfering with those behaviors. Another potential outcome of being "lost in the crowd" is the bystander effect, or the diffusion of responsibility in a group setting. In a large group, each individual believes that another has taken or will take responsibility, which can lead to inaction. Group composition’s effects of making the individual lost in the crowd or the center of attention are not inherently good or bad; positive or negative effects depend on the context.




Group Density

Another facet of the topography of the group that is related to group size is density. Density refers to the amount of space per person in the group (the less space per person, the higher the density). Doubling the number of people in the group meeting in a room of a given size will decrease by one-half the amount of space available for each member of the group. Alternatively, halving the number of people in the group will double the amount of space available per person. Thus, in a room of a given size, density is directly linked to the size of the group. This particular approach to density is called "social density," because it involves a change in density by manipulation of the social dimension (group size). One could also manipulate the physical dimension (room size), rendering a change in what is called "spatial density." Thus, halving the size of the room will halve the amount of space available to each group member.


Density has been demonstrated to influence a variety of social behaviors. People have been found to report feeling more anxious, more aggressive, more unpleasant, and, understandably, more crowded as a function of density. An analysis of the effects of “tripling” in college dormitories illustrates these types of effects. As a cost-cutting measure, colleges and universities will often house three students in a dormitory room that was initially constructed for two (hence, tripling). Tripling has been demonstrated to lead to an increase in arguments among the roommates, increased visits to the student health center, decreased grades, and increased overall dissatisfaction.




Role in Behavior and Identity

Groups exert sometimes dramatic, sometimes subtle influences on behavior. These influences are sometimes beneficial and sometimes detrimental. An understanding of the effect of groups on the individual sets the stage for a deeper understanding of many facets of social life. One of the reasons for the formation or joining of groups is the definition of the self. On a commonly used questionnaire that requires a person to respond twenty times to the question “Who am I?,” people tend to respond with references to some sort of group membership, be it family, occupation, hobby, school, ethnic, religious, or neighborhood. Groups help establish one’s identity, both for one’s own benefit and for the benefit of others with whom one interacts.




Costs of Group Membership

Belonging to groups has its price, however; as discussed at length by Christian Buys, one’s very membership in a group may carry with it hidden costs, risks, or sacrifices. A more complete understanding of groups requires a consideration of this aspect of membership in a group. Attaining certain types of rewards may be incompatible with belonging to a group. For example, the goal of completing a difficult and complicated task may be facilitated by belonging to a group of coworkers who bring the varied skills and knowledge required for successful task completion. Yet one group member’s goal of always being the center of attention, or of needing to feel special and unique, may have to be subverted if the group is to perform the task for which it formed. What the individual wants or needs may sometimes be displaced by what the group needs.


Moreover, the
deindividuation (an individual’s loss of self-awareness, resulting in a breakdown in the capacity to self-regulate) fostered by groups breaks down the individual’s ability to self-regulate. Research has demonstrated the state of deindividuation to increase the simulated electric shocks people will deliver to other people in experiments, to increase the use of profanity, and to increase stealing among Halloween trick-or-treaters. The paradigmatic illustration of the negative effects of deindividuation is the lynch mob. An analysis of newspaper accounts, conducted by Brian Mullen, of lynch-mob atrocities committed in the United States over a sixty-year period showed that the savagery and atrocity of the mob toward its victim(s) increased as the size of the mob increased relative to the number of its victims.




Group Membership Benefits

Yet, as discussed by Lynn Anderson, just as there are costs involved in belonging to a group, there are also benefits that accrue from group membership. Although the negative aspects of group membership may capture one’s attention more forcefully, the positive aspects are no less common or important. A complete understanding of the purpose of groups requires a consideration of the positive side of belonging to a group. A considerable amount of evidence has documented the physiological, attitudinal, and health effects of social support. For example, people who belong to a varied and tight social support network have been found to be in better physical health and to be better able to resist stress than those lacking such support. As examples, one might consider the effects of such popular support groups as Alcoholics Anonymous and Mothers Against Drunk Driving as well as less popular support groups that deal with specific issues such as loss and bereavement. These groups provide the imperative psychological function of allowing their members a new avenue for coping with their problems.


Perhaps the most notable effects of the group on self-definition and identity are observed when these taken-for-granted benefits are taken away. The woman who has defined herself in terms of her marital status can find herself in the midst of an identity crisis after a divorce. Similarly, foreign-exchange students often report dislocation or disorientation of identity immediately on their return home. After months or years of trying to establish a new identity based on new friends, new social contexts, or new groups, that new identity is now inappropriate and out of place in the old social context.




Bibliography


"Biker Pulled from Fiery Wreck Thanks 'Heroes.'" CBS News. CBS Interactive, 15 Sept. 2011. Web. 20 May 2014.



Brown, Rupert, ed. Group Processes: Dynamics within and between Groups. 2nd rev. ed. New York: Basil Blackwell, 2007. Print.



Canetti, Elias. Crowds and Power. Trans. Carol Stewart. 1962. New York: Noonday, 1998. Print.



"Florida Mom, Three Kids Rescued after Minivan Sinks into the Ocean." Good Morning America. ABC News, 5 Mar. 2014. Web. 20 May 2014.



Forsyth, Donalson R. Group Dynamics. 6th ed. Belmont: Wadsworth, 2014. Print.



Kirkpatrick, David D. "Egyptian Soccer Riot Kills More than 70, and Many Blame Military." New York Times 2 Feb. 2012: A10. Print.



Kirst-Ashman, Karen K. Human Behavior in the Macro Social Environment: An Empowerment Approach to Understanding Communities, Organizations, and Groups. 4th ed. Belmont: Brooks/Cole, 2014. Print.



Mullen, Brian, and George R. Goethals, eds. Theories of Group Behavior. New York: Springer-Verlag, 1987. Print.



Turner, John C., et al. Rediscovering the Social Group: A Self-Categorization Theory. New York: Basil Blackwell, 1988. Print.

What are natural treatments for cardiomyopathy?


Introduction


Cardiomyopathy is a little-understood condition in which the
muscle tissue of the heart becomes diseased. There are several distinct forms of
cardiomyopathy that may or may not be similar in origin. Medical treatment
consists mainly of medications that attempt to compensate for the increasing
failure of the heart to function properly. A heart
transplant may ultimately be necessary.






Proposed Natural Treatments


Coenzyme Q
10. Preliminary evidence suggests that the naturally occurring
substance coenzyme Q10 (CoQ10) might offer benefit in some
forms of cardiomyopathy. In a six-year trial, 143 people with moderately severe
cardiomyopathy were given CoQ10 daily in addition to standard medical
care. The results showed a significant improvement in cardiac function
(technically, ejection fraction) in 84 percent of the study participants. Most of
them improved by several stages on a scale that measures the severity of
heart
failure (technically, as classified by the New York Heart
Association). Furthermore, a comparison with persons on conventional therapy alone
appeared to show a reduction in mortality.


This study was an open trial, meaning that participants knew that they were being treated, and such studies are not fully reliable. There have been a few double-blind, placebo-controlled trials of CoQ10 in cardiomyopathy too. One such trial followed eighty people with various forms of cardiomyopathy for three years. Of those treated with CoQ10, 89 percent improved significantly, but when the treatment was stopped, their heart function deteriorated. No benefit was seen in another double-blind study, but it was a smaller and shorter trial and enrolled only people who had one particular type of cardiomyopathy (idiopathic dilated cardiomyopathy).



Carnitine. A small amount of evidence indicates that the vitamin-like supplement carnitine may be useful in cardiomyopathy.




Herbs and Supplements to Use Only with Caution

Various herbs and supplements may interact adversely with drugs used to treat cardiomyopathy, so one should be cautious when considering the use of herbs and supplements.




Bibliography


Langsjoen, H., et al. “Usefulness of Coenzyme Q10 in Clinical Cardiology.” Molecular Aspects of Medicine 15, suppl. (1994): S165-S175.



Nodari, S., et al. “The Role of N-3 PUFAs in Preventing the Arrhythmic Risk in Patients with Idiopathic Dilated Cardiomyopathy.” Cardiovascular Drugs and Therapy 23 (2008): 5-15.



Pepine, C. J. “The Therapeutic Potential of Carnitine in Cardiovascular Disorders.” Clinical Therapeutics 13 (1991): 2-21.



Winter, S., et al. “The Role of L-carnitine in Pediatric Cardiomyopathy.” Journal of Child Neurology 10, suppl. 2 (1995): S45-S51.

Monday, March 17, 2014

Why does Hamlet call the world "an unweeded garden"?

Hamlet is comparing humanity to the things growing in an unweeded garden that grows to seed. Such neglected gardens are commonly seen where houses have been standing vacant for a long time. Hamlet says that things rank and gross possess them merely.



Fie on't! ah, fie! 'tis an unweeded garden
That grows to seed; things rank and gross in nature
Possess it merely.



There is a distinct difference between "rank" and "gross." Ornamental vegetation that is rank is overgrown, choked, entangled. Lawns will become rank if they are not regularly mowed. They are an ugly sight. It is unusual for a poet to create ugly imagery as a metaphor to represent an ugly condition. The rank vegetation represents the ugliness that Hamlet sees in ordinary men. Growths in neglected gardens that can be called "gross" are not rank but stand out separately, towering over the rest. Milkweeds are a common sight in neglected gardens. They are tall, ugly, misshapen, grotesque. They seem to flaunt their ugliness. They bear flowers, but the flowers are colorless, ugly and randomly placed on the crooked stalks. Hamlet might have been thinking of King Claudius as one of the "gross" specimens of humanity.


Most people would probably not stop and spend time looking at an unweeded garden that grows to seed. They are depressing spectacles, but Shakespeare obviously appreciated them as lessons from reality and as potential metaphors and similes. He was not solely interested in pretty sights or in creating aesthetically pleasing imagery. He was more interested in expressing truth than in flattering nature. Some of his characters are beautiful examples of ugly people, including Iago, Caliban, Edmund, Regan, and Polonius. These characters are "gross." Characters like Rosencrantz and Guildenstern might be considered "rank." There are two of them but they seem like Siamese twins.

Why couldn't Macbeth kill Macduff?

If the question is referring to the combat between Macbeth and Macduff in the final scene of the play, then the answer is one of two things, depending on your interpretation of the play's major themes. Either Macduff was simply a better warrior and fighter than Macbeth, and therefore bested him in combat, or Macbeth was fated to die at the hands of Macduff. This seems to be Macbeth's view as soon as he finds out that Macduff was "not of woman born." However, if the question is referring to his intent to murder Macduff in Act IV, then the answer is simpler. As Lennox tells him in Act IV, Scene 1, Macduff has fled to England, perhaps seeing the handwriting on the wall. There he is under the protection of the King of England and cannot be reached. In a sign that he has truly become a brutal, murderous tyrant, he determines to have Macduff's family killed anyway:



The castle of Macduff I will surprise,
Seize upon Fife; give to the edge o’ the sword
His wife, his babes, and all unfortunate souls
That trace him in his line.



This horrific act is carried out in the next scene, and Macduff swears himself to revenge when he learns of it later.

Sunday, March 16, 2014

What arguments from Nicomachean Ethics would Aristotle use to defend abortion in extreme cases?

There is a cultural assumption here that makes the question somewhat complicated and difficult to answer without being anachronistic. While abortion is an ethically controversial topic in Christian culture, Aristotle lived over 300 years before the birth of Christ in a culture that did not particularly value the lives of infants, possibly due to a high infant mortality rate. It was considered perfectly acceptable to expose an unwanted baby on a hillside. Although the technology of safe abortions had not yet been invented, Aristotle's acceptance of infanticide would suggest that he would have found abortion completely acceptable in all circumstances.


The main argument in Aristotle's Nicomachean Ethics which would be relevant to this is his notion of humanity as defined by rationality. Our ethical obligations, according to Aristotle, are to rational beings. Thus a foetus or baby, lacking the ability to speak (a clear marker of rationality for Aristotle) or reason would not be considered fully human and we therefore would have no ethical obligations towards it. The ethical issue would simply be whether continuing to carry the foetus would contribute to the mother's well-being. In most cases, even in normal pregnancies, legal abortions by a qualified doctor are actually safer for the mother and have fewer complications than childbirth, and thus Aristotelian ethics would suggest that all abortions are ethically valid choices.

What are the internal conflicts in Flowers for Algernon?

Flowers for Algernon is about a developmentally disabled man named Charlie Gordon who undergoes a surgical procedure to increase his conventional intelligence. A mouse named Algernon has already undergone this procedure and has increased its intelligence. The internal conflict that results from the surgery, which makes Charlie into a conventionally "smart" person, is that he loses touch with his previous life and becomes more aware of his painful connections with other people.


For example, as Charlie gets conventionally smarter, he realizes that his co-workers at the factory he works at were mainly interested in making fun of him. In the letters that make up the novel, he writes, "I'm still a little angry that all the time people were laughing and making fun of me because I wasn't so smart." Eventually, he is fired from the factory because, as one of his former co-workers tells him, "It was evil when Eve listened to the snake and ate from the tree of knowledge." Charlie's co-workers feel left behind and offended when he becomes so much more intelligent. In addition, Charlie begins to develop a relationship with his teacher, Miss Kinnian, but when he becomes very advanced, he no longer has much in common with her.


Eventually, Charlie's intelligence declines, as the effects of the operation are not permanent, and Algernon, the mouse, dies. Charlie finds that he can't really connect with the people he was formerly friends with, including his co-workers at the factory and Miss Kinnian, and he decides to leave New York and go elsewhere to start a new life. 

Saturday, March 15, 2014

What would make a good introductory sentence for a summary of The Fault in Our Stars?

Think of an introductory sentence for a book summary like a topic sentence or thesis statement. It should be a strong, thought-provoking statement that tells your reader specifically what you will address. Since this is a summary and not an argumentative or persuasive essay, all you need to do is decide on a dominant theme or character and write about that to begin with. In this case, it's Hazel Grace. One might also focus on how Hazel's life ties into the title of the book, which also creates a theme. The following are examples you might use: 


1.  John Green's The Fault in Our Stars centers around a cancer-fighting teenager who unexpectedly finds love and doesn't die. 


2. It isn't Hazel's fault that she doesn't die and Gus does; but, the stars never seem to shine brightly for young love.


3. If stars really do drive a person's fate, then yes, Hazel's are to blame for Gus dying; but, they are also the reason she fell in love with him first.

What is the significance of the church fire scene in The Outsiders? How does it help the characters develop?

During the church fire scene in Chapter 6, Ponyboy, Johnny, and Dally develop as characters, as their actions are brave and responsible. When Ponyboy sees the church on fire, he immediately feels responsible for having started it by smoking inside the church and rushes into the church to help the children who are trapped inside. He thinks to himself, "All I could think was: We started it. We started it. We started it!" (page numbers vary by edition). Johnny, who also takes responsibility for possibly starting the fire, is right behind him. Johnny tells the trapped children he's in charge—which is a change from his previous frightened behavior. Ponyboy says of Johnny, "He wasn't scared either. That was the only time I can think of when I saw him without that defeated, suspicious look in his eyes. He looked like he was having the time of his life" (page numbers vary by edition). While Johnny's experiences have left him scared and vulnerable, rescuing the children from the fire allows him to display a brave and commanding side of himself that appears to liberate him in some ways.


Later, Ponyboy learns from Jerry, the man in the ambulance that is taking him to the hospital, that Dally went into the church to rescue Johnny, an act that also showed immense courage. Jerry says to Ponyboy, "I swear, you three are the bravest kids I've seen in a long time" (page numbers vary by edition). The significance of the church fire is that it allows all three characters to put into action the brave and selfless sides of themselves that they are not always able to show in everyday life.

Friday, March 14, 2014

What is acetaminophen? How does it interact with other drugs?


Milk Thistle, Coenzyme Q10 (CoQ10), Methionine


Effect: Possible Helpful Interactions




The herb milk thistle and the supplements CoQ10 and methionine might help protect the liver against damage caused by excessive use of acetaminophen. However, it is extremely dangerous to take excessive amounts of acetaminophen.




Vitamin C


Effect: Possible Increased Risk of Toxicity


One study from the 1970s suggests that very high doses of vitamin C (3
grams daily) might increase the levels of acetaminophen in the body. This could
potentially put a person at higher risk for acetaminophen toxicity. Problems might
occur if one takes higher-than-recommended doses or takes high doses of
acetaminophen on a regular basis, such as for osteoarthritis. The risk increases if one has liver or
kidney impairment or drinks alcoholic beverages regularly, which further harms the
liver.




Chaparral, Comfrey, and Coltsfoot


Effect: Possible Harmful Interaction


The herbs chaparral (Larrea tridentata or L. mexicana), comfrey (Symphytum officinale), and coltsfoot (Tussilago farfara) contain liver-toxic substances. Combined use with acetaminophen could accentuate the liver toxicity of the medication.




Citrate


Effect: Possible Harmful Interaction


Potassium citrate, sodium citrate, and potassium-magnesium citrate are
sometimes used to prevent kidney stones. These supplements reduce
urinary acidity and can therefore lead to decreased blood levels and decreased
effectiveness of acetaminophen.




Bibliography


Muriel, P., et al. “Silymarin Protects Against Paracetamol-Induced Lipid Peroxidation and Liver Damage.” Journal of Applied Toxicology 12 (1992): 439-442.



Neuvonen, P. J., et al. “Methionine in Paracetamol Tablets: A Tool to Reduce Paracetamol Toxicity.” International Journal of Clinical Pharmacology, Therapy, and Toxicology 23 (1985): 497-500.




2011 PDR for Nonprescription Drugs, Dietary Supplements, and Herbs. Toronto, Ont.: Thomson Health Care, 2010.

Why was the Plessy v. Ferguson case important to the era of segregation?

The Plessy V. Ferguson case in 1896 started segregation as a legal entity in the United States.  In 1892, Homer Plessy, a man who was one eighth black, violated Louisiaina's Separate Car Act which required whites and blacks use separate rail cars.  The penalty for violating this act was $25 or twenty days in jail.  Plessy's argument was that this law violated the Thirteenth and Fourteenth Amendments to the U.S. Constitution, the first of which prohibited slavery and the second one that is credited with making the former slaves American citizens. The majority opinion of the Supreme Court ruled that "the Fourteenth Amendment gave all citizens equal status before the law," but it said nothing about giving people separate access to public utilities.  This created the "separate but equal" amenities that would be in much of the South until the early 1960s.   There would be separate lunch counters, schools, water fountains, and bathrooms, and often these would not be of the same quality that whites got to use.  

Thursday, March 13, 2014

What was the South African government like under Apartheid?

Between 1948 and 1994, South Africa’s government was ruled by the National Party, which instituted the system known as Apartheid. In creating Apartheid, the National Party’s goal was to ensure that Afrikaners, white descendants of 17th century Dutch settlers, maintained political control in post-colonial South Africa. The Apartheid era was defined by extreme segregation and oppression; the legacy of which South Africa continues to grapple with more than two decades later.


Throughout the 1950s, the National Party stripped voting rights away from black South Africans, along with other minorities described under the umbrella term ‘Coloureds.’ The National Party did this by manipulating the court system and passing a series of laws in the legislature which it controlled. By 1960, black South Africans had lost their right to vote.


Though Afrikaners were the majority white population in South Africa, other whites such as the descendants of English settlers, along with a sizable Jewish community, were weary of the Afrikaners’ dominance of South Africa’s political system. Though Afrikaner politicians attempted to strengthen ‘white unity’ through declaring South Africa a republic in 1960, groups within South Africa’s white community continued to distrust one another until the end of the Apartheid era.


Throughout the 1960s and 1970s, the Apartheid government attempted to gain international support through its anti-Communist policies. Though America was learning many valuable lessons concerning racial equality from the Civil Rights Movement, the American government continued to support South Africa through the mid 1980s as part of its strategy to win the Cold War against the Soviet Union. In fact, it was the U.S.’s Central Intelligence Agency that assisted the Apartheid government in arresting Nelson Mandela, who at the time was affiliated with the South African Communist Party.


On the home front, the National Party continued its oppression of ‘Coloured’ South Africans by relocating millions of people to a series of ‘Bantustans,’ quasi-independent countries located in some of South Africa’s most inhospitable areas. In the Bantustans, education, sanitation, and other social services were severely limited. By the mid-1980s, life for white South Africans was comparable to living in wealthier areas of the United States. Life for black South Africans, however, was at Third World poverty levels.


The world turned against South Africa's Apartheid government throughout the 1980s. Trade sanctions placed on South Africa by nearly two dozen countries severely weakened South Africa’s economy. Combined with the condemnation of Apartheid by religious leaders such as Pope John Paul II, the National Party began to re-evaluate its stance on Apartheid. A defining moment came in 1989 when F.W. de Klerk became South Africa’s president. Though a conservative, de Klerk understood that Apartheid could no longer exist. De Klerk lifted restrictions on previously banned political parties such as the African National Congress. His efforts also led to the release of Nelson Mandela from prison in 1990.


After two years of negotiations, South Africa had its first free elections in 1994. Nelson Mandela was elected president, and the African National Congress, once labeled a terrorist organization by the National Party, became the majority political party in the country’s legislature. Apartheid was officially over.

Wednesday, March 12, 2014

In Chapter 17 of Into the Wild by Jon Krakauer, what important guiding tool does Chris get rid of?

That chapter is a really difficult chapter to read, emotionally at least. I may have thought that McCandless was a bit crazy at different times throughout the book, but I always admired his ability to survive on so little.  I may have thought him odd, but I also never thought him stupid--until Chapter 17.  The guiding tool that McCandless chose to do without while on his Alaskan adventure was a topographic map.  Had McCandless had a topographic map of the area surrounding the bus, he would have seen that he was close to a USGS gauging station.  The gauging station had been decommissioned, but it still had the cable crossing in place to allow transit across the river.  Had McCandless had the topographic map, he would have seen how close he really was to being able to survive.  



When McCandless tried to walk out of the bush one year ago the previous week, the basket was in the same place it is now, on his side of the canyon. If he’d known about it, crossing the Teklanika to safety would have been a trivial matter. Because he had no topographic map, however, he had no way of conceiving that salvation was so close at hand.


Tuesday, March 11, 2014

Referencing Harper Lee's To Kill a Mockingbird, how might I write four diary entries from either Bob Ewell's or Mayella Ewell's perspective?

This is an interesting assignment. It might be easier to choose to write from Mayella's perspective because young girls usually write in diaries, not older men. One entry could be about what actually happened on the day she trapped and kissed Tom Robinson; the next would could be about being beat up by her father and lying to the police about it; then, the third one could be about how she feels the night before the trial; and the fourth one could be about her feelings after the trial.


The first entry would show Mayella talking about Tom Robinson being handsome and kind to her. She likes him because he is kind to her and speaks to her kindly as well. Her white pride might come into her reasoning that if she can make a black man do chores for her, she could kiss him, and he wouldn't say anything about it because it would be her word against his. This entry should also include the plan about how she sends her siblings off with nickels for ice-cream so she and Tom can be alone. She would end the entry saying that her father will be gone hunting, so he shouldn't be a problem either.


The second entry would be from the night she gets caught by her father with Tom Robinson. She would describe how humiliated and embarrassed she was when her father looked through the window and screamed her name as she was hugging Tom. Then she would describe how her father beat her up to make it look like a rape. She would include what she is supposed to tell the sheriff when he got there to take a statement, too. In the end, she would justify her lying by saying that Tom deserves what he gets because he's black. Mayella would show no real concern for Tom because she acted out of selfishness.


The third entry could be written the night before the trial. She would mention that she actually took a bath for the event and how easy it should all go over because the case is based on two white people's testimonies over that of a black man's. She would probably mention that she is nervous to take the stand because she has heard that Atticus Finch actually cares about defending Tom honorably; but, she would brush those fears away thinking that a white man will support his kind in the end.


Finally, the fourth entry would be full of hate and animosity towards Atticus Finch for making a fool out of her father when he was on the stand. Then she would complain about how he made her cry and mocked her by calling her "ma'am" most of the time. She would also praise herself for saying the following:



"I got somethin' to say an' then I ain't gonna say no more. That ni**** yonder took advantage of me an' if you fine fancy gentlemen don't wanta do nothin' about it then you're all yellow stinkin' cowards, stinkin' cowards, the lot of you. Your fancy airs don't come to nothin'. . . Mr. Finch" (188).



Of course she would end by being overjoyed that the jury sided in her favor and didn't let Tom go. She would say that Tom deserved everything he got for being who he is.

Monday, March 10, 2014

Name an aspect of science that helps us in our lives.

As Maniac meets more people, he sees that not everyone is "color blind" the way he is. Why do you think Manic is "color blind"?

Part of the reason Maniac Magee might be "color blind" is that he has had such a difficult life. His parents died when he was very young, and he lived with his aunt and uncle, who hate each other. When Maniac finds Amanda Beale in Chapter 3, she is friendly to him when he asks her about the suitcase she is carrying. Maniac doesn't care that in the East End, all the kids are black. He thinks "He and Amanda and the suitcase were like a rock in a stream" (page 11). She provides friendship and stability for him in his unstable world.


Because he is running away from his old life, and he has never learned about racial prejudice, he doesn't understand the distinctions that other people make between black and white. 



"Maniac loved the colors of the East End. The people colors. For the life of him, he couldn't figure out why these East Enders called themselves black. He kept looking and looking, and the colors he found were gingersnap and light fudge and dark fudge and acorn and butter rum and cinnamon and burnt orange. But never licorice, which, to him, was real black" (page 51).



The only thing Maniac cares about is that people accept him and are friendly to him, so he is essentially blind to the idea of a division between black and white.

What are hearing tests?

Indications and Procedures Hearing tests are done to establish the presence, type, and sever...