Early History
Biological warfare antedates by several centuries the discovery of the gene. Just as the history of genetics did not begin with Gregor Mendel, whose pea-plant experiments eventually helped found modern genetics, the history of biological warfare began long before the Japanese dropped germ-filled bombs on several Chinese cities during World War II. For example, the Assyrians, six centuries before the common era, knew enough about rye ergot, a fungus disease, to poison their enemies’ wells. The ancient Greeks also used disease as a military weapon, and the Romans catapulted diseased animals into enemy camps. A famous medieval use of biological weapons occurred during the Tatar siege of Kaffa, a fortified Black Sea port, then held by Christian Genoans. When Tatars started dying of the bubonic plague, the survivors catapulted cadavers into the walled city. Many Genoans consequently died of the plague, and the remnant who sailed back to Italy contributed to the spread of the Black Death into Europe.
Once smallpox was recognized as a highly contagious disease, military men made use of it in war. For example, the conquistador Francisco Pizarro
presented South American natives with smallpox-contaminated clothing, and, in an early case of ethnic cleansing, the British and Americans used deliberately induced smallpox epidemics to eliminate native tribes from desirable land.
As scientists in the nineteenth and twentieth centuries learned more about the nature and modes of reproduction of such diseases as anthrax and smallpox, germ warfare began to become part of such discussions as the First International Peace Conference in The Hague (1899). The worldwide revulsion against the chemical weapons used in World War I, along with a concern that biological weapons would be more horrendous, led to the Geneva Protocol (1925), which prohibited the first use of germ weapons, but not their development.
From Germ Warfare to Genetic Weapons
With the accelerating knowledge about the genetics of various disease-causing microorganisms, several countries became concerned with the threat to their security posed by the weaponizing of these pathogens. Although several states signed the Geneva Protocol in the late 1920s, others signed only after assurances of their right to retaliate. The United States, which did not ratify the treaty until 1975, did extensive research on germ weapons during the 1950s and 1960s. American scientists were able to make dry infectious agents that could be packed into shells and bombs, and estimates were made that ten airplanes with such bombs could kill or seriously disable tens of millions of people. Unknown to Congress and the American people, tests using apparently harmless microbes were performed on such large communities as San Francisco. When news of these secret tests was made public, many questioned their morality. Extensive criticism of the research and development of these weapons, together with the realization that these weapons posed a threat to the attackers as well as the attacked, led President Richard Nixon to end the American biological weapons program formally in 1969.
Abhorrence of biological weapons extended to the world community, and in 1972 the Biological and Toxin Weapons Convention (BTWC)—a treaty that prohibited the development, production, and stockpiling of bacteriological weapons—was signed in Washington, DC, London, and Moscow and was put into force in 1975. Although it was eventually signed by most members of the United Nations, the nations that signed the pact failed to reach agreement on an inspection system that would control the proliferation of these weapons. A pivotal irony of the BTWC is that while most of the world was renouncing germ warfare, biologists were learning how to manipulate DNA, the molecule that carries genetic information, in powerful new ways. This knowledge made possible the creation of “superbugs,” infectious agents for which there are no cures.
Some scientists warned the public and international agencies about these new germ weapons. Other investigators discovered that American researchers were creating infectious agents that would confuse diagnosticians and defeat vaccines. Similarly, Soviet researchers on an island in the Aral Sea, described as the world’s largest biological weapons test site, were producing germ weapons that could be loaded on missiles. When Boris Yeltsin became president of Russia, he discovered that the secret police and military officials had misinformed him about these programs, in which deadly accidents had occurred. Also troubling was the spread of biological agents to such countries as Iraq. American and French companies legally shipped anthrax and botulinum bacteria to Iraq, whose scientists later acknowledged that they had used these microbes to make tons of biological weapons during the 1980s.
With the demise of the Soviet Union and increasing violence in the Balkans and Middle East, politicians became fearful that experts who had dedicated their careers to making biological weapons would now sell their knowledge to rogue nations or terrorist groups. Indeed, deadly pathogens were part of world trade, since the line separating legitimate and illegitimate research, defensive and offensive biological weapons, was fuzzy. In the 1980s members of a religious cult spread salmonella, a disease-causing bacterium, in an Oregon town, causing more than seven hundred people to become very ill. The same company that sold salmonella to this religious cult also sold pathogens to the University of Baghdad. Bioterrorism had become both a reality and a threat.
The Future of Genetic Weapons
Some scientists and politicians believe that a nation’s best defense against bioterrorism is advanced genetic knowledge, so that vaccines can be tailored to respond to traditional and new biological weapons. For example, the Human Genome Project, which succeeded in mapping the human genetic material, has the potential for revealing both the vulnerabilities and defenses of the immune system. (The human genome sequence contains 3.2 billion bases and approximately 34,000 genes. These data freely are available on the Internet in a variety of forms, including text files and graphical “genome browsers.”) On the other hand, such knowledge could prove dangerous if the genetic vulnerabilities of certain ethnic groups could be targeted by bioengineered microbes. Some scientists find these speculations about genocidal biological weapons unevidenced and unsubstantial. Genetic similarities between different ethnic groups are more significant than their differences. Other scientists point out that dramatic genetic differences between ethnic groups are a reality. Believers in ethnic biological weapons point to existing techniques for selectively killing certain cells and for inactivating certain DNA sequences. These techniques, developed with the hope of curing genetic diseases, could also be used to cause harm. Knowledge of the structure of the human genome will increasingly lead to knowledge of its function, and this knowledge will make it possible to manipulate, in both benign and malign ways, these information-laden molecules. Modern biotechnology thus presents humanity with both a great promise, to better health and life in peace, and a great peril, to multiply sickness and death in war. The hope of many scientists, politicians, and ordinary people is that humanity will choose the path of promise.
Key terms
anthrax
:
an acute bacterial disease that affects animals and humans and that is especially deadly in its pulmonary form
biological weapon
:
the military or terrorist use of such organisms as bacteria and viruses to cause disease and death in people, animals, or plants
bioterrorist
:
an individual or group that coercively threatens or uses biological weapons, often for ideological reasons
ethnic weapons
:
genetic weapons that target certain racial groups
genetic engineering
:
the use of recombinant DNA to alter the genetic material in an organism
immune system
:
the biological defense mechanism that protects the body from disease-causing microorganisms
recombinant DNA
:
DNA prepared by transplanting and splicing genes from one species into the cells of another species
smallpox
:
an acute, highly infectious, often fatal disease characterized by fever followed by the eruption of pustules
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