Calcium and Vitamin D
Effect: Possible Decreased Action of Drug
Taking calcium and vitamin D supplements might interfere
with some of the effects of calcium channel blockers.
Ginkgo biloba
Effect: Possible Decreased Action of Drug
According to a study in rats, ginkgo extract may cause the body to metabolize some calcium channel blockers more rapidly, thereby decreasing their effects.
Naringen (Citrus Bioflavonoid)
Effect: May Necessitate Reduction in Drug Dosage
Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug. This may necessitate a reduction in drug dosage.
Bibliography
Guadagnino, V., et al. “Treatment of Severe Left Ventricular Dysfunction with Calcium Chloride in Patients Receiving Verapamil.” Journal of Clinical Pharmacology 27 (1987): 407-409.
Kuhn, M., and D. L. Schriger. “Low-Dose Calcium Pretreatment to Prevent Verapamil-Induced Hypotension.” American Heart Journal 124 (1992): 231-232.
Luscher, T. F., et al. “Calcium Gluconate in Severe Verapamil Intoxication.” New England Journal of Medicine 330 (1994): 718-720.
Margolis, K. L., et al. “Effect of Calcium and Vitamin D Supplementation on Blood Pressure.” Hypertension 52 (2008): 847-855.
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